Ключевое слово: «cervical cancer»

Cancers of the female reproductive system are among the most common types of cancer. This problem is particularly acute in countries with underdeveloped healthcare systems. The goal was to develop a device that would reduce costs and improve the effectiveness of radiation therapy, particularly intraoperative radiation therapy (IORT). North-Eastern Federal University and the Yakutsk Republican Oncology Center, together with Tomsk Polytechnic University, are developing a compact Betatron CMB-8 radiation therapy device. To develop a therapeutic unit based on this device, it is necessary to study the characteristics of this accelerator's beam level under various conditions, observing accelerated electrons on red blood cells from patients diagnosed with breast cancer (BC) and cervical cancer (CC). The results obtained will also help determine the potential for using the Betatron CMB-8 in clinical practice.

Cervical cancer remains one of the most widespread malignancies among women worldwide, emphasizing the need for innovative, non-invasive diagnostic techniques. This study explores the structural and biochemical alterations in hemoglobin extracted from patients with cervical cancer through Raman and infrared (IR) spectroscopy. These methods allow the detection of molecular-level changes in blood components, offering a potential diagnostic approach for early-stage disease identification. A total of 20 blood samples from patients diagnosed with cervical cancer and 11 control samples from healthy female donors were analyzed. Distinct spectral shifts in amide I and amide II bands, as well as alterations in heme-associated Raman bands, were identified. The observed spectral variations indicate changes in the conformation and oxygenation state of hemoglobin in cancer patients. These findings highlight the diagnostic potential of vibrational spectroscopy in identifying biochemical markers associated with cervical cancer