Keyword: «инновация»
The article touches upon the key issues of the management of the innovation system of Russian regions in the conditions of global instability and the possibility of unpredictable abrupt development of international relations, the consequences of which are fraught with a high level of political uncertainty. The concepts of innovative development and diffuse innovation are clarified, the fundamental principles of the state innovation policy to stimulate the market of the innovative regional system are presented; the structure of the innovation system of regions (ISR) is given, the basics of interaction of ISR subjects in the process of creating innovations are revealed; the problems of Russian regions with low potential for innovative development are identified and ways to solve them are proposed. The relevance of the study is due to the lag of Russia from the developed countries of the West in the field of high technologies and knowledge-intensive produc-tion.Unfortunately, at this time in the modern scientific literature on regional economics there is a lack of fundamental scientific research on the problems of managing innovation systems of regions in conditions of global instability.